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Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19

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Cranberry-Almond No-Bake Energy Bites

Cranberry-Almond No-Bake Energy Bites You can add 1 tablespoon of chia seeds or ground flaxseed to oat mixture in step 1, if desired. Energy bites can be refrigerated in an airtight container for up to three days. Makes 12 bites Total Time: 15 minutes, plus 30 minutes chilling time Gather Equipment: Dry measuring cups Measuring spoons Large bowl Rubber spatula Plate Plastic wrap Prepare Ingredients: 3/4 cup (2 1/4 ounces) old-fashioned rolled oats聽 1/3 cup peanut, almond, or sunflower butter聽 1/3 cup sliced almonds聽 1/3 cup dried cranberries聽 2 tablespoons honey 1/8 teaspoon salt Mix:聽Stir all ingredients in bowl with rubber spatula until well combined. Shape:聽Use your wet hands to roll mixture into 12 balls (about 1 tablespoon each). Place balls on plate and cover with plastic wrap.聽 Chill:聽Refrigerate balls…

Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19

Researchers have identified dozens of drugs and compounds, some experimental and others already approved by health authorities, that may be effective in combating the CCP virus.

The Epoch Times refers to the novel聽coronavirus, also called SARS-CoV-2, as the聽CCP virus聽because the Chinese Communist Party鈥檚 coverup and mishandling allowed the virus to spread throughout China and spark a global pandemic.

In a preprint study not yet peer-reviewed, published on March 22 on聽bioRxiv, the research team indicated it found hundreds of “high confidence” interactions between SARS-CoV-2 virus proteins and druggable human proteins.

Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19

Nearly 70 substances, including聽both drugs in clinical trials and those already approved by the Food and Drug Administration (FDA), as well as preclinical compounds, have the potential to impact the virus, the team found.

“Among these, we identify 66 druggable human proteins or host factors targeted by 69 existing FDA-approved drugs, drugs in clinical trials and/or preclinical compounds, that we are currently evaluating for efficacy in live SARS-CoV-2 infection assays,” the team wrote.

The fact that the human proteins, or host factors, are impacted by existing drugs and experimental compounds makes it more likely to identify “effective molecular targets” that potential antiviral therapeutics based on these drugs or compounds could hit.

“The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains,” the researchers concluded.

The list includes聽chloroquine, which kills a parasite that causes malaria. The drug can also interact with a human protein called the sigma-1 receptor, the same one the CCP virus attacks.

Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19 3D print of a spike protein of SARS-CoV-2鈥攚hich The Epoch Times refers to as the CCP virus, the pathogen that causes COVID-19鈥攊n front of a 3D print of a SARS-CoV-2 virus particle. The spike protein (foreground) enables the virus to enter and infect human cells. On the virus model, the virus surface (blue) is covered with spike proteins (red) that enable the virus to enter and infect human cells. (Courtesy of NIAID/RML)

Chloroquine

President Donald Trump has referred to chloroquine optimistically in terms of potential effectiveness against the virus.

Chloroquine, or hydroxychloroquine, is approved by the FDA for treatment of malaria, lupus, and rheumatoid arthritis, but not for COVID-19, the disease caused by the CCP virus.

Last week, the FDA approved chloroquine and remdesivir聽to treat patients with COVID-19 under the “compassionate use” framework.

This lets doctors use experimental treatments or medications that have been approved for other ailments to treat COVID-19 patients. Under this model, medical practitioners are required to share all patient info regarding administration of and response to the drug, thereby helping inform ongoing trials and regulatory initiatives.

Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, said the drug’s potential effectiveness against the virus was based anecdotal evidence and that clinical trials were needed to bear out the hypothesis.

Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19

Former FDA commissioner Dr. Scott Gottlieb, told CBS News that the study that looked at chloroquine involved around 20 patients, and only six cases saw benefit.

“And the benefit that they showed was that they decrease the amount of virus in their noses when you did nasal swabs in those patients,” Gottlieb said. “So it could very well be that the drug is reducing viral shedding, but having no impact on the clinical course of those patients. So the data on that is very preliminary.”

Still, New York State Governor Andrew Cuomo announced Sunday聽that the state had obtained a large quantity of聽chloroquine and would be proceeding with trial use of the drug.

Speaking at a briefing at New York City鈥檚 Javits Center on Tuesday, Cuomo said COVID-19 was spreading in the region like a “bullet train.”

“New York is the canary in the coal mine, New York is happening first, what is happening to New York will happen to California and Illinois, it is just a matter of time,” Cuomo said.

He also said New York would be experimenting with splitting ventilators, of which the state needs at least 30,000 more, and which for some patients will聽“make the difference between life and death.”

“We haven鈥檛 flattened the curve,” he said. “The apex is higher than we thought and the apex is sooner than we thought. That is a bad combination of facts.”

This article is from the Internet:Scientists Find 69 Drugs and Compounds Potentially Effective Against COVID-19

Applesauce Mini Muffins

Muffins can be stored at room temperature in a zipper-lock bag for up to three days or frozen for up to one month. If muffins are frozen, thaw at room temperature, and then refresh muffins by placing them on a rimmed baking sheet and warming them in a 300-degree oven for about 10 minutes. Makes 24 mini muffins Total Time: 45 minutes Gather Equipment: Dry measuring cups Measuring spoons Small microwave-safe bowl and plate Liquid measuring cup 24-cup mini muffin tin 2 bowls (1 large, 1 medium) Whisk Rubber spatula 2 spoons Toothpick Oven mitts Cooling rack Prepare Ingredients: Vegetable oil spray 1 1/2 cups (7 1/2 ounces) all-purpose flour 1 teaspoon baking soda 1/2 teaspoon salt 1/2 teaspoon ground cinnamon 1 cup unsweetened applesauce 8 tablespoons unsalted butter, melted and…